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urokinase type plasminogen activator upa  (Innovative Research Inc)


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    Innovative Research Inc urokinase type plasminogen activator upa
    Urokinase Type Plasminogen Activator Upa, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 93/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/urokinase type plasminogen activator upa/product/Innovative Research Inc
    Average 93 stars, based on 19 article reviews
    urokinase type plasminogen activator upa - by Bioz Stars, 2026-03
    93/100 stars

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    HBV DNA, HBeAg, and HBsAg decline and transient increase in ALT in C57BL/6 and C57BL/6 <t>SCID</t> mice after HAP-1 treatment. (A) C57BL/6 and C57BL/6 <t>SCID</t> <t>mice</t> that lack mature B and T lymphocytes were transduced with 1 × 1011 vg equivalents AAV-HBV and treated orally for 28 days with HAP-1 (36 mg/kg QD) or placebo. (B and C) Plots represent HBV DNA and HBeAg levels in plasma during treatment duration. (D) Correlation plot is shown between HBsAg levels and ALT increase in plasma during treatment duration. QD, once daily; vg, viral genome; LLOQ, lower limit of quantification. Data are shown as mean ± SEM and represent groups of five mice.
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    HBV DNA, HBeAg, and HBsAg decline and transient increase in ALT in C57BL/6 and C57BL/6 SCID mice after HAP-1 treatment. (A) C57BL/6 and C57BL/6 SCID mice that lack mature B and T lymphocytes were transduced with 1 × 1011 vg equivalents AAV-HBV and treated orally for 28 days with HAP-1 (36 mg/kg QD) or placebo. (B and C) Plots represent HBV DNA and HBeAg levels in plasma during treatment duration. (D) Correlation plot is shown between HBsAg levels and ALT increase in plasma during treatment duration. QD, once daily; vg, viral genome; LLOQ, lower limit of quantification. Data are shown as mean ± SEM and represent groups of five mice.

    Journal: Journal of Virology

    Article Title: Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation

    doi: 10.1128/jvi.01502-23

    Figure Lengend Snippet: HBV DNA, HBeAg, and HBsAg decline and transient increase in ALT in C57BL/6 and C57BL/6 SCID mice after HAP-1 treatment. (A) C57BL/6 and C57BL/6 SCID mice that lack mature B and T lymphocytes were transduced with 1 × 1011 vg equivalents AAV-HBV and treated orally for 28 days with HAP-1 (36 mg/kg QD) or placebo. (B and C) Plots represent HBV DNA and HBeAg levels in plasma during treatment duration. (D) Correlation plot is shown between HBsAg levels and ALT increase in plasma during treatment duration. QD, once daily; vg, viral genome; LLOQ, lower limit of quantification. Data are shown as mean ± SEM and represent groups of five mice.

    Article Snippet: Male HBV-genotype-C-infected uPA/SCID chimeric mice (PXB-Mouse; 21–25 weeks of age; weight, 17.8–23.0 g) were from PhoenixBio (Higashi-Hiroshima, Japan).

    Techniques: Transduction